What additional clues can help diagnosis any bipolar disorder?

1. Family history of bipolar. Bipolar is one of the most highly inherited psychiatric conditions.
2. Antidepressant reactions. In bipolar depression, these antidepressant responses make a psychiatrist suspect bipolar:
   1. Poor response to three or more antidepressants
   2. Hypomanic or manic episode in response to an antidepressant
   3. Pattern of good response to antidepressant that fades away
   4. Acceleration of mood swings in response to antidepressant